top of page
Exeter Fast HDX equipment.jpg
Science of HDX

The Science of HDX

HDX basics_edited.jpg

Longer incubation of protein in D O → more deuterium incorporation = ↑ mass seen in peptides in mass spectrometer


Low v High affinity FastHDX advantages.jpg


Our proprietary FastHDX approach is based on 50 years experience in high speed liquid exchange.  It enables us to easily 'see' low affinity binding typical of early hits generated in fragment-based allosteric drug design programmes that cannot normally be seen with standard HDX.

bottom of page